Association Nationale des Centres d'IVG et de Contraception

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Pain during medical abortion : a multicenter study in France, EJOG, 2016-11, Vol. 194, pp. 212-217

Auteurs : Marie-Josèphe Saurel-Cubizolles, Marion Opatowski, Philippe David, Françoise Bardy, Annabel Dunbavand

DOI : http://dx.doi.org/10.1016/j.ejogrb.2015.09.025

EJOG : European of Obstetrics and Gynecology and Reproductive Biologie

Source : EJOG

Abstract Objective
To compare the level of pain reported by women by dose of mifepristone, 200 or 600 mg, and describe the main factors related to the pain level in the 5 days after a medical abortion.

Study design
Observational study in 11 medical centers in France between October 2013 and September 2014. The protocols were 200 or 600 mg orally mifepristone on day 1 of the medical abortion and 400, 600 or 800 μg orally misoprostol   on day 3. Women returned a questionnaire that they completed during 5 days following the abortion ; pain was recorded on a visual analog scale (0–10) daily.

Results
453 women were included ; the mean age was 29 years (range 18–49 years). Pain was greater with 200 than 600 mg mifepristone : 33% of women reported a pain level of ≥8 on day 3 with 200 mg as compared with 16% with 600 mg. This difference remained after controlling for age, gestational age, gravidity, usual painful menstruation and misoprostol   dose.

Percentages of symptoms as vomiting or diarrhea were also lower with 600 mg mifépristone   than 200 mg.

Conclusion
The mean pain severity experienced by women undergoing medical abortion is high ; it is higher with a regimen of 200 mg mifepristone. The findings emphasize the need to improve analgesic strategies and invite to opt for a protocol of 600 mg instead of 200 mg mifepristone.

Keywords :
Pain, Medical abortion, Mifépristone